Maternal Serum, Cord and Human Milk Levels of Per- and Polyfluoroalkyl Substances (PFAS), Association with Predictors and Effect on Newborn Anthropometry

The understanding of per- and polyfluoroalkyl substances (PFAS) health effects is rapidly advancing among critical populations. Therefore, the objective of this study was to assess PFAS serum levels among Lebanese pregnant women, cord serum and human milk levels, their determinants, and effects on n...

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Published in:Toxics (Basel) 2023-05, Vol.11 (5), p.455
Main Authors: Mahfouz, Maya, Harmouche-Karaki, Mireille, Matta, Joseph, Mahfouz, Yara, Salameh, Pascale, Younes, Hassan, Helou, Khalil, Finan, Ramzi, Abi-Tayeh, Georges, Meslimani, Mohamad, Moussa, Ghada, Chahrour, Nada, Osseiran, Camille, Skaiki, Farouk, Narbonne, Jean-François
Format: Article
Language:English
Subjects:
Accreditation
Anthropometry
Breast milk
Consumption
Contamination
cord
Dairy products
Development
Diet
Drinking water
Environmental aspects
Fetal blood
Health aspects
human biomonitoring
human milk
Incineration
Infants
Ions
Laboratories
Life Sciences
Liquid chromatography
Milk
newborn
Perfluoroalkyl & polyfluoroalkyl substances
Perfluorooctane sulfonic acid
Perfluorooctanoic acid
perinatal exposure
persistent organic pollutants
Prenatal influences
Serum levels
Shellfish
Subgroups
Womens health
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Summary:The understanding of per- and polyfluoroalkyl substances (PFAS) health effects is rapidly advancing among critical populations. Therefore, the objective of this study was to assess PFAS serum levels among Lebanese pregnant women, cord serum and human milk levels, their determinants, and effects on newborn anthropometry. We measured concentrations of six PFAS (PFHpA, PFOA, PFHxS, PFOS, PFNA and PFDA) using liquid chromatography MS/MS for 419 participants, of which 269 had sociodemographic, anthropometric, environmental and dietary information. The percentage of detection for PFHpA, PFOA, PFHxS and PFOS was 36.3-37.7%. PFOA and PFOS levels (95th percentile) were higher than HBM-I and HBM-II values. While PFAS were not detected in cord serum, five compounds were detected in human milk. Multivariate regression showed that fish/shellfish consumption, vicinity to illegal incineration and higher educational level were associated with an almost twice higher risk of elevated PFHpA, PFOA, PFHxS and PFOS serum levels. Higher PFAS levels in human milk were observed with higher eggs and dairy products consumption, in addition to tap water (preliminary findings). Higher PFHpA was significantly associated with lower newborn weight-for-length Z-score at birth. Findings establish the need for further studies, and urgent action to reduce exposure among subgroups with higher PFAS levels.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics11050455