Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

Current research has demonstrated that mitochondrial morphology, distribution, and function are maintained by the balanced regulation of mitochondrial fission and fusion, and perturbation of the homeostasis between these processes has been related to cell or organ dysfunction and abnormal mitochondr...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-01, Vol.18 (1), p.144-144
Main Authors: Hu, Chenxia, Huang, Yong, Li, Lanjuan
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Disease
dynamin-related protein 1
Dynamins - metabolism
fission
fusion
Humans
mammal
Mammals - metabolism
mitochondria
Mitochondrial Dynamics
Morphology
Protein Processing, Post-Translational
Review
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Summary:Current research has demonstrated that mitochondrial morphology, distribution, and function are maintained by the balanced regulation of mitochondrial fission and fusion, and perturbation of the homeostasis between these processes has been related to cell or organ dysfunction and abnormal mitochondrial redistribution. Abnormal mitochondrial fusion induces the fragmentation of mitochondria from a tubular morphology into pieces; in contrast, perturbed mitochondrial fission results in the fusion of adjacent mitochondria. A member of the dynamin family of large GTPases, dynamin-related protein 1 (Drp1), effectively influences cell survival and apoptosis by mediating the mitochondrial fission process in mammals. Drp1-dependent mitochondrial fission is an intricate process regulating both cellular and organ dynamics, including development, apoptosis, acute organ injury, and various diseases. Only after clarification of the regulative mechanisms of this critical protein in vivo and in vitro will it set a milestone for preventing mitochondrial fission related pathological processes and refractory diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18010144