Capturing the multifaceted function of adipose tissue macrophages

Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabol...

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Bibliographic Details
Published in:Frontiers in immunology 2023-02, Vol.14, p.1148188
Main Authors: Matz, Alyssa J, Qu, Lili, Karlinsey, Keaton, Vella, Anthony T, Zhou, Beiyan
Format: Article
Language:English
Subjects:
Adipocytes
Adipogenesis
Adipose Tissue
Humans
immune response
Immunology
macrophage
Macrophages
Obesity
single-cell RNA sequencing
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Summary:Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabolism, extracellular remodeling, and supporting angiogenesis and adipogenesis. Thus, high-resolution methods are needed to capture macrophages' dynamic and multifaceted functions in adipose tissue. Herein, we review current knowledge on regulatory networks critical to macrophage plasticity and their multifaceted response in the complex adipose tissue microenvironment.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1148188