Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission r...

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Bibliographic Details
Published in:One health 2021-12, Vol.13, p.100350-100350, Article 100350
Main Authors: Ji, Yunpeng, Li, Pengfei, Jia, Yueqi, Wang, Xiaohua, Zheng, Qinyue, Peppelenbosch, Maikel P., Ma, Zhongren, Pan, Qiuwei
Format: Article
Language:English
Subjects:
Foodborne transmission
HEV
Mathematical modeling
Research Paper
Vaccine
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Summary:Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.
ISSN:2352-7714
2352-7714
DOI:10.1016/j.onehlt.2021.100350