DMFDMA catalyzed synthesis of 2-((Dimethylamino)methylene)-3,4-dihydro-9-arylacridin-1(2H)-ones and their derivatives: in-vitro antifungal, antibacterial and antioxidant evaluations

A series of 3,4-dihydro-9-arylacridin-1(2 )-ones was synthesized and enaminone function was introduced at the C-2 position using DMFDMA catalyst which in turn successfully converted into pyrazole, isoxazol, 1-phenyl-1 -pyrazole by treating it with reagents such as hydrazine, hydroxylamine and phenyl...

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Bibliographic Details
Published in:Open Chemistry 2018-10, Vol.16 (1), p.1077-1088
Main Authors: Jyothish Kumar, L., Sarveswari, S., Vijayakumar, V.
Format: Article
Language:English
Subjects:
antibacterial
antifungal
antioxidant evaluations
DMFDMA
Enaminones
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Summary:A series of 3,4-dihydro-9-arylacridin-1(2 )-ones was synthesized and enaminone function was introduced at the C-2 position using DMFDMA catalyst which in turn successfully converted into pyrazole, isoxazol, 1-phenyl-1 -pyrazole by treating it with reagents such as hydrazine, hydroxylamine and phenylhydrazine. These newly synthesized compounds were evaluated for their antibacterial activity against a series of Gram-Positive bacteria including Staphylococcus , Bacillus , Staphylococcus MLS16 and Gram-Negative bacteria including Klebsiella , Escherichia and Pseudomonas and also against fungal strains including Candida , Candida , Candida , Candida , Aspergillus and Issatchenkia . The compounds and exhibited considerable antifungal activity (MIC value 0.007 and 0.006 μM) against Candida and Aspergillus respectively. The compound showed excellent antibacterial activity towards Escherichia (MIC = 0.003 μM) and the compound found to show prominent DPPH radical scavenging activity with EC value 16.85±1.5μg mL
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2018-0110