Yin Yang 1 expression predicts a favourable survival in diffuse large B-cell lymphoma

• Published in: Heliyon 2024-01, Vol.10 (2), p.e24376-e24376, Article e24376
• Main Authors: Xue, Tian, Lin, Jia-Xin, He, Ya-Qi, Li, Ji-Wei, Liu, Ze-Bing, Jia, Yi-Jun, Zhou, Xiao-Yan, Li, Xiao-Qiu, Yu, Bao-Hua
• Format: Article
• Language: English
• Subjects: CXCR4; Diffuse large B-Cell lymphoma; Double-expression; Overall survival; pAKT; Yin yang 1
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e24376

Yin Yang 1 (YY1) is a multifunctional transcription factor that plays an important role in tumour development and progression, while its clinical significance in diffuse large B-cell lymphoma (DLBCL) remains largely unexplored. This study aimed to investigate the expression and clinical implications of YY1 in DLBCL. YY1 expression in 198 cases of DLBCL was determined using immunohistochemistry. The correlation between YY1 expression and clinicopathological parameters as well as the overall survival (OS) and progression-free survival (PFS) of patients was analyzed. YY1 protein expression was observed in 121 out of 198 (61.1 %) DLBCL cases. YY1 expression was significantly more frequent in cases of the GCB subgroup than in the non-GCB subgroup (P = 0.005). YY1 was positively correlated with the expression of MUM1, BCL6, pAKT and MYC/BCL2 but was negatively associated with the expression of CXCR4. No significant relationships were identified between YY1 and clinical characteristics, including age, sex, stage, localization, and B symptoms. Univariate analysis showed that the OS (P = 0.003) and PFS (P = 0.005) of patients in the YY1-negative group were significantly worse than those in the YY1-positive group. Multivariate analysis indicated that negative YY1 was a risk factor for inferior OS (P