A cross-sectional study of clinical, dermoscopic, histopathological, and molecular patterns of scalp melanoma in patients with or without androgenetic alopecia

Scalp melanoma (SM) has a worse prognosis than melanoma in other locations likely because of late diagnosis due to hair coverage, difficulties in interpreting dermoscopy findings, and its unique molecular profile. We aimed to describe the clinical, histopathological, molecular, and dermoscopic patte...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-09, Vol.12 (1), p.15096-15096, Article 15096
Main Authors: Porto, Ana Carolina, Pinto Blumetti, Tatiana, Calsavara, Vinícius Fernando, Tardin Torrezan, Giovana, Andrade de Paula, Cláudia Alessandra, Lellis, Rute, Pedreira Duprat Neto, João, Carraro, Dirce Maria, Casagrande Tavoloni Braga, J.
Format: Article
Language:English
Subjects:
631/67/1813/1634
692/699/4033/1813/1634
Alopecia
Baldness
Cross-sectional studies
Diagnosis
Hair
Humanities and Social Sciences
Melanoma
multidisciplinary
Mutation
Neurofibromin 1
Patients
Prognosis
Scalp
Science
Science (multidisciplinary)
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scalp melanoma (SM) has a worse prognosis than melanoma in other locations likely because of late diagnosis due to hair coverage, difficulties in interpreting dermoscopy findings, and its unique molecular profile. We aimed to describe the clinical, histopathological, molecular, and dermoscopic patterns of SM and its relation to androgenetic alopecia/elastosis at the tumor site. Through a retrospective cross-sectional study, we identified all SM diagnosed at the A.C.Camargo Cancer Center between 2008 and 2018. In all, 48 SM were analyzed: 45.8% of which exhibited moderate/severe androgenetic alopecia and 54.1% exhibited elastosis. Androgenetic alopecia/elastosis at the site of the SM was associated with older age ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-17108-z