Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran

Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in individuals...

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Published in:Scientific reports 2022-05, Vol.12 (1), p.8254-8254, Article 8254
Main Authors: Shamsedini, Narges, Dehghani, Mansooreh, Samaei, Mohammadreza, Azhdarpoor, Aboolfazl, Hoseini, Mohammad, Fararouei, Mohammad, Bahrany, Shayan, Roosta, Sareh
Format: Article
Language:English
Subjects:
692/1537
692/53
704/172
C-reactive protein
Creatinine
Cross-Sectional Studies
Environmental Monitoring
Environmental risk
Health risk assessment
Health risks
Humanities and Social Sciences
Humans
Iran
Metabolites
multidisciplinary
Oxidation
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - analysis
Restaurants
Risk Assessment
Science
Science (multidisciplinary)
Toxic substances
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Summary:Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in individuals living near restaurants via a health risk assessment analysis. This cross-sectional study was performed on 57 people living near restaurants and 30 individuals as the control group. Five urinary metabolites of PAHs were monitored. In order to evaluate the effects of the urinary metabolites of PAHs on Malondialdehyde (MDA) concentration, Total Anti-oxidation Capacity (TAC) in urine samples, and C-Reactive Protein (CRP) in serum samples, regression model was used by considering the effects of the possible confounding factors. Non-carcinogenic health risk was calculated, as well. The median concentration of urinary PAHs was 1196.70 and 627.54 ng/g creatinine in the people living near restaurants and the control group, respectively. Among the metabolites, the lowest and highest mean concentrations were related to 9-OHPhe and 1-OHP, respectively in the two study groups. Moreover, PAHs were significantly associated with MDA level and TAC ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-12040-8