Regulatory Mechanisms of Autophagy-Targeted Antimicrobial Therapeutics Against Mycobacterial Infection

(Mtb) is an intracellular pathogen causing human tuberculosis, an infectious disease that still remains as a global health problem. Autophagy, a lysosomal degradative process, has emerged as a critical pathway to restrict intracellular Mtb growth through enhancement of phagosomal maturation. Indeed,...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2021-03, Vol.11, p.633360-633360
Main Authors: Silwal, Prashanta, Paik, Seungwha, Kim, Jin Kyung, Yoshimori, Tamotsu, Jo, Eun-Kyeong
Format: Article
Language:English
Subjects:
AMPK
autophagy
Cellular and Infection Microbiology
host-directed therapeutics
mTOR
Mycobacterium tuberculosis
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Summary:(Mtb) is an intracellular pathogen causing human tuberculosis, an infectious disease that still remains as a global health problem. Autophagy, a lysosomal degradative process, has emerged as a critical pathway to restrict intracellular Mtb growth through enhancement of phagosomal maturation. Indeed, several autophagy-modulating agents show promise as host-directed therapeutics for Mtb infection. In this Review, we discuss recent progress in our understanding the molecular mechanisms underlying the action of autophagy-modulating agents to overcome the immune escape strategies mediated by Mtb. The factors and pathways that govern such mechanisms include adenosine 5'-monophosphate-activated protein kinase, Akt/mammalian TOR kinase, Wnt signaling, transcription factor EB, cathelicidins, inflammation, endoplasmic reticulum stress, and autophagy-related genes. A further understanding of these mechanisms will facilitate the development of host-directed therapies against tuberculosis as well as infections with other intracellular bacteria targeted by autophagic degradation.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.633360