Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo

Histone deacetylases (HDACs) are conserved enzymes that remove acetyl groups from lysine side chains in histones and other proteins and play a crucial role in epigenetic regulation. Previously, we showed that histone acetylation is implicated in ultraviolet (UV)-induced inflammation and matrix impai...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-02, Vol.22 (4), p.2032
Main Authors: Lee, Yuri, Shin, Mi Hee, Kim, Min-Kyoung, Kim, Yeon Kyung, Shin, Hye Sun, Lee, Dong Hun, Chung, Jin Ho
Format: Article
Language:English
Subjects:
acetylated histone H3
Acetylation - radiation effects
histone deacetylase
Histone Deacetylases - metabolism
Histones - metabolism
Humans
Mitochondrial Proteins - metabolism
sirtuin
Sirtuins - metabolism
Skin - metabolism
Skin - radiation effects
skin aging
Skin Aging - radiation effects
ultraviolet
Ultraviolet Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Histone deacetylases (HDACs) are conserved enzymes that remove acetyl groups from lysine side chains in histones and other proteins and play a crucial role in epigenetic regulation. Previously, we showed that histone acetylation is implicated in ultraviolet (UV)-induced inflammation and matrix impairment. To elucidate the histone acetylation status and specific HDACs involved in skin aging, we examined the changes in histone acetylation, global HDAC activity, and the expression of HDACs and sirtuins (SIRTs) in intrinsically aged and photoaged human skin as well as in UV-irradiated human skin in vivo. Following acute UV irradiation, the acetylated histone H3 (AcH3) level was increased, but HDAC activity and the expression levels of HDAC4, HDAC11, and SIRT4 were significantly decreased. In intrinsically aged skin, AcH3 levels were increased, but HDAC activity and the expression levels of HDAC4, HDAC5, HDAC10, HDAC11, SIRT6, and SIRT7 were significantly decreased. However, histone acetylation and HDAC expression in photoaged skin were not significantly different from those in intrinsically aged skin. Collectively, HDAC4 and HDAC11 were decreased in both UV-irradiated and intrinsically aged skin, suggesting that they may play a universal role in increased histone acetylation associated with skin aging.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22042032