Cytokines in innate and acquired immunity to Trypanosoma cruzi infection

Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-alpha, IFN-gamma and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of th...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 1998-01, Vol.31 (1), p.117-121
Main Author: Abrahamsohn, I A
Format: Article
Language:English
Subjects:
Animals
BIOLOGY
Cytokines - physiology
Immunity - physiology
Immunity, Innate - physiology
innate immunity
Interferon-gamma
Interleukin-10
Interleukin-12
knock-out mice
MEDICINE, RESEARCH & EXPERIMENTAL
Mice
Mice, Knockout
TNF-alpha
Trypanosoma cruzi
Trypanosoma cruzi - pathogenicity
Trypanosomiasis - immunology
Tumor Necrosis Factor-alpha
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Summary:Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-alpha, IFN-gamma and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-gamma and TNF-alpha in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed.
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/S0100-879X1998000100015