Targeting Metabolic-Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy

Drug resistance is currently one of the biggest challenges in cancer treatment. With the deepening understanding of drug resistance, various mechanisms have been revealed, including metabolic reprogramming and alterations of redox balance. Notably, metabolic reprogramming mediates the survival of tu...

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Bibliographic Details
Published in:Antioxidants 2024-07, Vol.13 (7), p.828
Main Authors: Wang, Yuke, He, Jingqiu, Lian, Shan, Zeng, Yan, He, Sheng, Xu, Jue, Luo, Li, Yang, Wenyong, Jiang, Jingwen
Format: Article
Language:English
Subjects:
Antioxidants
Cancer therapies
Cell cycle
Cell death
Chemical bonds
Chemotherapy
Dehydrogenases
dietary interventions
DNA damage
DNA repair
Drug delivery
Drug metabolism
Drug resistance
Enzymes
Harsh environments
Homeostasis
Kinases
Localization
Metabolism
Oxidation
Oxidative stress
Phosphatase
Proteins
Reactive oxygen species
redox modification
ROS
Signal transduction
Tumor cells
Tumors
Citations: Items that this one cites
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Summary:Drug resistance is currently one of the biggest challenges in cancer treatment. With the deepening understanding of drug resistance, various mechanisms have been revealed, including metabolic reprogramming and alterations of redox balance. Notably, metabolic reprogramming mediates the survival of tumor cells in harsh environments, thereby promoting the development of drug resistance. In addition, the changes during metabolic pattern shift trigger reactive oxygen species (ROS) production, which in turn regulates cellular metabolism, DNA repair, cell death, and drug metabolism in direct or indirect ways to influence the sensitivity of tumors to therapies. Therefore, the intersection of metabolism and ROS profoundly affects tumor drug resistance, and clarifying the entangled mechanisms may be beneficial for developing drugs and treatment methods to thwart drug resistance. In this review, we will summarize the regulatory mechanism of redox and metabolism on tumor drug resistance and highlight recent therapeutic strategies targeting metabolic-redox circuits, including dietary interventions, novel chemosynthetic drugs, drug combination regimens, and novel drug delivery systems.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13070828