Inflammatory markers and indicators of systemic endotoxemia in patients with treatment-resistant schizophrenia

IntroductionElevated levels of lipopolysaccharide (LPS) in circulation support chronic inflammation, which is involved in the pathological process in the brain and may be a contributing factor to treatment resistance in schizophrenia.ObjectivesTo compare inflammatory markers and indicators of system...

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Published in:European psychiatry 2023-03, Vol.66 (S1), p.S247-S248
Main Authors: Zozulya, S A, Otman, I N, Anikhovskaya, I A, Tikhonov, D V, Kaleda, V G, Yakovlev, M Y, Klyushnik, T P
Format: Article
Language:English
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Inflammation
Schizophrenia
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Summary:IntroductionElevated levels of lipopolysaccharide (LPS) in circulation support chronic inflammation, which is involved in the pathological process in the brain and may be a contributing factor to treatment resistance in schizophrenia.ObjectivesTo compare inflammatory markers and indicators of systemic endotoxemia (SE) in patients with treatment-resistant schizophrenia and in those with a good response to treatment.MethodsThe study involved 34 patients with schizophrenia (27±7,5 years) (F20) in an acute psychotic state: 15 patients with TRS (non-responders), 19 patients responded to treatment with reduced symptoms (responders). The markers of systemic inflammation (leukocyte elastase (LE) and a1-proteinase inhibitor (α1-PI) activity, CRP concentration, antibodies (Abs) to S100B and myelin basic protein) and the indicators of SE (LPS level and Abs to LPS) were determined in the blood of patients.ResultsThe responders showed a significant increase in LE and α1-P1 activity (p
ISSN:0924-9338
1778-3585
DOI:10.1192/j.eurpsy.2023.568