Patients taking angiotensin-converting enzyme inhibitors/angiotensin II type I receptor blockers: higher risks of severe acute respiratory syndrome coronavirus 2 infection but milder clinical manifestations?

[...]can ACEIs/ARBs actually up-regulate ACE2 levels? [7–9] ACE2 downregulation could lead to the angiotensin II/angiotensin II type 1 receptor (AT1R)-induced aggravation of lung injury or acute lung failure according to several animal findings of virus infection (severe acute respiratory syndrome c...

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Bibliographic Details
Published in:Chinese medical journal 2020-11, Vol.133 (22), p.2650-2652
Main Authors: Deng, Jie-Lin, Jiang, Yun-Qiu, Guo, Yan-Kai, Li, Hong-Liang
Format: Article
Language:English
Subjects:
Angiotensin II Type 1 Receptor Blockers - adverse effects
Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Betacoronavirus
Blood pressure
Clinical medicine
Coronavirus Infections - etiology
Coronaviruses
COVID-19
Diuretics
Enzymes
Gene expression
Humans
Infections
Pandemics
Peptidyl-Dipeptidase A - physiology
Pneumonia, Viral - etiology
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral infections
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Summary:[...]can ACEIs/ARBs actually up-regulate ACE2 levels? [7–9] ACE2 downregulation could lead to the angiotensin II/angiotensin II type 1 receptor (AT1R)-induced aggravation of lung injury or acute lung failure according to several animal findings of virus infection (severe acute respiratory syndrome coronavirus/H5N1). The median difference in the likelihood of testing positive or having severe disease was not significant between ACEIs/ARBs users and non-users. Besides these controllable factors, genetic predisposition is also associated with an increased risk of SARS-CoV-2 infection.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000000996