The Urinary Metabolome of Healthy Newborns

The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate's metabolism, or to assess their general health status. For full term-newborns, many reference biochemical va...

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Bibliographic Details
Published in:Metabolites 2020-04, Vol.10 (4), p.165
Main Authors: López-Hernández, Yamilé, Oropeza-Valdez, Juan José, Blanco-Sandate, Jorge O, Herrera-Van Oostdam, Ana Sofia, Zheng, Jiamin, Chi Guo, An, Lima-Rogel, Victoria, Rajabzadeh, Rahmatollah, Salgado-Bustamante, Mariana, Adrian-Lopez, Jesus, Castillo, C G, Robles Arguelles, Emilia, Monárrez-Espino, Joel, Mandal, Rupasri, Wishart, David S
Format: Article
Language:English
Subjects:
Babies
Cerebrospinal fluid
Gender differences
Hematology
inborn errors of metabolism
Infants
Literature reviews
Males
Mass spectrometry
Mass spectroscopy
Medical screening
Metabolism
Metabolites
Metabolomics
Neonates
newborn
Newborn babies
reference values
Scientific imaging
Sex differences
tandem mass spectrometry
Urine
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Summary:The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate's metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo10040165