Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review

Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with...

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Bibliographic Details
Published in:Renal failure 2024-12, Vol.46 (1), p.2323160-2323160
Main Authors: Chen, Zewei, Xu, Dechao, Cui, Fangzheng, Hou, Huihui, Mao, Zhiguo, Gao, Xiang
Format: Article
Language:English
Subjects:
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Anti-glomerular basement membrane disease
Anti-Glomerular Basement Membrane Disease - complications
Anti-Glomerular Basement Membrane Disease - diagnosis
Autoantibodies
Autoimmune diseases
Basement membranes
Biopsy
Coexistence
crescentic glomerulonephritis
Female
Glomerulonephritis
Glomerulonephritis and Immunologic Disorders
Glomerulonephritis, IGA - complications
Glomerulonephritis, IGA - diagnosis
Humans
IgA nephropathy
Immunoglobulin A
Immunoglobulin G
Literature reviews
prognosis
Renal function
Review
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Summary:Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output. A renal biopsy revealed crescent glomerulonephritis with lineal IgG deposition along the GBM and mesangial IgA deposition, which supported the diagnosis of concurrent anti-GBM disease and IgA nephropathy (IgAN). In an extensive literature review, we identified a total of thirty-nine patients were reported anti-GBM disease combined with IgAN. The clinical characteristics of these patients demonstrate that the anti-GBM disease combined with IgAN tends to be milder with a more indolent course and a better prognosis than the classic anti-GBM disease, and its potential pathogenesis deserves to be further explored.
ISSN:0886-022X
1525-6049
DOI:10.1080/0886022X.2024.2323160