Advanced Diagnostic Techniques in Autoimmune Bullous Diseases

Autoimmune blistering diseases are diverse group of conditions characterized by blisters in the skin with or without mucosal lesions. There may be great degree of clinical and histopathological overlap; hence, advanced immunological tests may be necessary for more precise diagnosis of these conditio...

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Bibliographic Details
Published in:Indian journal of dermatology 2017-05, Vol.62 (3), p.268-278
Main Authors: Jindal, Anuradha, Rao, Raghavendra, Bhogal, Balbir S
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoimmune bullous diseases
Autoimmune diseases
Dermatitis
Dermatology
Diagnosis
direct immunofluorescence
Disease
ELISA
Enzymes
IJD Symposium
Immunoglobulins
Laboratories
Medical diagnosis
Microscopy
Pathogenesis
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Description
Summary:Autoimmune blistering diseases are diverse group of conditions characterized by blisters in the skin with or without mucosal lesions. There may be great degree of clinical and histopathological overlap; hence, advanced immunological tests may be necessary for more precise diagnosis of these conditions. Direct immunofluorescence microscopy is the gold standard tests to demonstrate the tissue-bound antibodies and should be done in all cases. Magnitude of antibody level in patient' serum can be assessed by indirect immunofluorescence and enzyme linked immunosorbent assay. In this article we have reviewed the various techniques that are available in the diagnosis of autoimmune blistering diseases.
ISSN:0019-5154
1998-3611
DOI:10.4103/ijd.IJD_196_17