Allogeneic umbilical cord blood-derived mesenchymal stem cell implantation versus microdrilling combined with high tibial osteotomy for cartilage regeneration

This study compared cartilage regeneration outcomes in knee osteoarthritis (OA) using allogeneic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation and microdrilling with high tibial osteotomy (HTO). Fifty-four patients (60 knees) were included: 24 (27 knees) in the hUC...

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Bibliographic Details
Published in:Scientific reports 2024-02, Vol.14 (1), p.3333-3333, Article 3333
Main Authors: Jung, Se-Han, Nam, Bum-Joon, Choi, Chong-Hyuk, Kim, Sungjun, Jung, Min, Chung, Kwangho, Park, Jisoo, Jung, Youngsu, Kim, Sung-Hwan
Format: Article
Language:English
Subjects:
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Arthritis
Biomechanics
Bone surgery
Cartilage
Cartilage diseases
Cartilage, Articular - pathology
Cartilage, Articular - surgery
Clinical outcomes
Cord blood
Defects
FDA approval
Fetal Blood
Hematopoietic Stem Cell Transplantation
Hospitals
Humanities and Social Sciences
Humans
Knee
Medical schools
Medicine
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
multidisciplinary
Orthopedics
Osteoarthritis
Osteoarthritis, Knee - pathology
Osteoarthritis, Knee - surgery
Osteotomy
Range of motion
Regeneration
Review boards
Science
Science (multidisciplinary)
Second-Look Surgery
Stem cells
Surgical outcomes
Umbilical cord
University colleges
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Summary:This study compared cartilage regeneration outcomes in knee osteoarthritis (OA) using allogeneic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation and microdrilling with high tibial osteotomy (HTO). Fifty-four patients (60 knees) were included: 24 (27 knees) in the hUCB-MSC group and 30 (33 knees) in the microdrilling group. Both groups showed significant improvements in pain and functional scores at 6, 12, and 24 months compared to baseline. At 24 months, the hUCB-MSC group had significantly improved scores. Arthroscopic assessment at 12 months revealed better cartilage healing in the hUCB-MSC group. In subgroup analysis according to the defect site, hUCB-MSC implantation showed superior cartilage healing for anterior lesions. In conclusion, both treatments demonstrated effectiveness for medial OA. However, hUCB-MSC implantation had better patient-reported outcomes and cartilage regeneration than microdrilling. The study suggests promising approaches for cartilage restoration in large knee defects due to OA.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-53598-9