Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer

Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 wom...

Full description

Saved in:
Bibliographic Details
Published in:Journal of immunology research 2017-01, Vol.2017 (2017), p.1-6
Main Authors: Fan, Jiao, Chen, Cuina, Zhong, Yiping
Format: Article
Language:English
Subjects:
Abortion
Abortion, Spontaneous
Adult
Antibodies, Antinuclear - blood
Apoptosis
Autoimmune diseases
Biomarkers
Clinical Study
Cryopreservation
Deoxyribonucleic acid
DNA
DNA - blood
DNA - immunology
Drug dosages
Embryo Transfer
Embryos
Female
Fertilization in Vitro
Gene expression
Hospitals
Humans
Immunoglobulins
Immunology
In vitro fertilization
Infertility
Infertility, Female - blood
Infertility, Female - etiology
Laboratories
Lupus
Medicine
Oocytes - immunology
Oocytes - pathology
Physiology
Pregnancy
Quality
Reproductive health
Reproductive technologies
Retrospective Studies
Studies
Urine
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA− group), and 121 women with negative ANA and anti-dsDNA (ANA−/anti-dsDNA− group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (HRT-TET) cycle. We compared basic characters and IVF outcomes among three groups in fresh embryo transfer and frozen-thawed embryo transfer cycle, respectively. The number of retrieved oocytes, available embryos, and high-quality embryos in the ANA+/anti-dsDNA+ group was lower than those in the other two groups in the fresh embryo transfer cycle. The rates of fertilization, implantation, and clinical pregnancy in the ANA+/anti-dsDNA+ group were the lowest, while the early miscarriage rate was the highest in the ANA+/anti-dsDNA+ group both in the fresh embryo transfer cycle and in the frozen-thawed embryo transfer cycle. Our data suggested that anti-dsDNA antibody may be the essential marker for defective oocytes or embryos in infertile women with any type of ANA.
ISSN:2314-8861
2314-7156
DOI:10.1155/2017/8596181