Bone mineral density in children wth systemic lupus erythematosus and juvenile rheumatoid arthritis

Although there is increasing in bone metabolism in patients with rheumatic disorders, few data exist on bone mineral density (BMD) in children with rheumatic disorders or on the association of BMD with disease-related variables. We determined BMD in Iranian children with systemic lupus erythematosus...

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Bibliographic Details
Published in:Annals of Saudi medicine 2007-11, Vol.27 (6), p.427-431
Main Authors: Kashef, Sara, Saki, Forugh, Karamizadeh, Zohreh, Kashef, Mohammad Amin
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adolescent
Age Factors
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - physiopathology
Body Height
Body Weight
Bone Density - drug effects
Child
Cross-Sectional Studies
Dose-Response Relationship, Drug
Female
Femur Neck - diagnostic imaging
Glucocorticoids - administration & dosage
Glucocorticoids - adverse effects
Humans
Iran
Lumbar Vertebrae - diagnostic imaging
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - physiopathology
Male
Severity of Illness Index
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Summary:Although there is increasing in bone metabolism in patients with rheumatic disorders, few data exist on bone mineral density (BMD) in children with rheumatic disorders or on the association of BMD with disease-related variables. We determined BMD in Iranian children with systemic lupus erythematosus (SLE) and juvenile rheumatoid arthritis (JRA) to evaluate the relationship between disease-related variables and BMD. Twenty patients (13 girls and 7 boys) with SLE (n=15) and JRA (n=5) with a mean age of 13.10+/-3.29 years (range, 6-17 years), attending a pediatric rheumatology clinic and 20 healthy controls (matched for age and sex with each patient) were enrolled in a cross-sectional study between 2001 and 2003. BMD (g/cm(2)) of the femoral neck (BMD-F) and lumbar vertebrae (BMD-L) were measured by dual energy X-ray absorptiometry (DEXA). The correlation between BMD and cumulative dose of steroids, daily dose of steroid, disease duration, disease activity, height, weight, and age was investigated. BMD in the patients (BMD-F=0.72+/-0.15, BMD-L=0.70+/-0.19) was significantly lower than controls (BMD-F=0.95+/-0.17, BMD-L=0.98+/-0.20, P=
ISSN:0256-4947
0975-4466
DOI:10.4103/0256-4947.51458