Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score

• Published in: BMC infectious diseases 2012-08, Vol.12 (1), p.184-184, Article 184
• Main Authors: Travaglino, Francesco, De Berardinis, Benedetta, Magrini, Laura, Bongiovanni, Cristina, Candelli, Marcello, Silveri, Nicolò Gentiloni, Legramante, Jacopo, Galante, Alberto, Salerno, Gerardo, Cardelli, Patrizia, Di Somma, Salvatore
• Format: Article
• Language: English
• Subjects: Adolescent; Adrenomedullin - blood; Adult; Aged; Aged, 80 and over; Amino acids; APACHE; APACHE II score; Bacterial infections; Biomarkers; Calcitonin - blood; Calcitonin Gene-Related Peptide; Critical care; Critical Illness; Emergency medical care; Emergency Medical Services - methods; Ethics; Female; Fever; Fever - diagnosis; Hospitals; Humans; Infections; Male; Medicine; Mid regional pro-Adrenomedullin; Middle Aged; Mortality; Patients; Peptide Fragments - blood; Peptides; Procalcitonin; Prognosis; Protein Precursors - blood; Sepsis; Severity of Illness Index; Software; Statistical analysis; Viral infections; Young Adult
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/1471-2334-12-184

The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization. This was an observational, multicentric study. We enrolled 128 patients referred to the ED with high fever and a suspicion of severe infection such as sepsis, lower respiratory tract infections, urinary tract infections, gastrointestinal infections, soft tissue infections, central nervous system infections, or osteomyelitis. The APACHE II score was calculated for each patient. MR-proADM median values in controls were 0.5 nmol/l as compared with 0.85 nmol/l in patients (P