Astrocyte mitochondria: Potential therapeutic targets for epilepsy

Epilepsy is a chronic, relapsing neurological disorder, and current treatments focus primarily on neurons, yet one-third of patients still develop drug-resistant epilepsy. Therefore, there is an urgent need to explore new therapeutic targets. Interestingly, astrocytes can transfer their healthy mito...

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Bibliographic Details
Published in:Heliyon 2024-05, Vol.10 (9), p.e29950-e29950, Article e29950
Main Authors: Chen, Lu, Yang, Wenqian, Yang, Fei, Xu, Tingwan, Yu, Yanying, Wu, Qian, Han, Yanbing
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Astrocyte mitochondria
Calcium homeostasis
Epilepsy
Glutamate
Review
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Summary:Epilepsy is a chronic, relapsing neurological disorder, and current treatments focus primarily on neurons, yet one-third of patients still develop drug-resistant epilepsy. Therefore, there is an urgent need to explore new therapeutic targets. Interestingly, astrocytes can transfer their healthy mitochondria into neighboring neurons, thus preventing neuronal damage. Astrocyte mitochondria have been shown to have a therapeutic role in stroke and neurodegenerative diseases. However, their therapeutic effect in epilepsy and its related mechanisms have been less studied. In this review, we mainly summarize the regulatory role of astrocyte mitochondria in glutamate, calcium ion, and adenosine triphosphate (ATP) homeostasis and outline the protective role of astrocyte mitochondria in nervous system diseases, revealing a new target for epilepsy treatment.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e29950