Risk of incident autoimmune diseases in patients with newly diagnosed psoriatic disease: a nationwide population-based study

• Published in: Scientific reports 2023-10, Vol.13 (1), p.16738-16738, Article 16738
• Main Authors: Jung, Joon Min, Kim, Ye-Jee, Lee, Woo Jin, Won, Chong Hyun, Lee, Mi Woo, Chang, Sung Eun
• Format: Article
• Language: English
• Subjects: 692/699/1670; 692/699/249; 692/699/4033; Ankylosing spondylitis; Autoimmune diseases; Crohn's disease; Diabetes mellitus (insulin dependent); Disease; Graves' disease; Humanities and Social Sciences; multidisciplinary; Population studies; Population-based studies; Rheumatoid arthritis; Risk assessment; Science; Science (multidisciplinary); Sjogren's syndrome; Systemic lupus erythematosus; Systemic sclerosis; Ulcerative colitis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-43778-4

There are limited large population-based cohort studies on the risk of incident autoimmune diseases among patients with newly diagnosed psoriatic disease. The objective of this study was to assess the risk of autoimmune diseases in patients with newly diagnosed psoriatic disease. Using the Korean National Health Insurance Service database, patients with newly diagnosed psoriatic disease between 2007 and 2019 were included. Comparators were randomly selected and matched according to age and sex. A total of 321,354 patients with psoriatic disease and 321,354 matched comparators were included in this study. Patients with psoriatic disease had a significantly higher risk of Crohn’s disease [adjusted hazard ratio (aHR), 1.95; 95% confidence interval (CI) 1.42–2.67], ulcerative colitis (aHR, 1.65; 95% CI 1.39–1.96), systemic lupus erythematosus (aHR, 1.86; 95% CI 1.34–2.57), rheumatoid arthritis (aHR, 1.63; 95% CI 1.52–1.76), ankylosing spondylitis (aHR, 2.32; 95% CI 1.95–2.77), alopecia areata (aHR, 1.41; 95% CI 1.35–1.46), and type 1 diabetes (aHR, 1.23; 95% CI 1.11–1.37). However, the risk of Graves’ disease, Hashimoto’s disease, Sjögren’s syndrome, and systemic sclerosis was not significantly different between the groups. In conclusion, patients with newly diagnosed psoriatic disease may have a significantly increased risk of incident autoimmune diseases.