MIF contribution to progressive brain diseases

Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a process of...

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Bibliographic Details
Published in:Journal of neuroinflammation 2024-01, Vol.21 (1), p.8-8, Article 8
Main Authors: Matejuk, Agata, Benedek, Gil, Bucala, Richard, Matejuk, Szymon, Offner, Halina, Vandenbark, Arthur A
Format: Article
Language:English
Subjects:
Alzheimer's disease
Astrocytoma
Autoimmune diseases
B cells
Blood circulation disorders
Brain Diseases
Brain research
Brain tumors
Calgranulin A
Calgranulin B
Cancer
Cell growth
Central nervous system
Cytokines
Degeneration
Development and progression
Diseases
Glioblastoma
Gliomas
Homeostasis
Humans
Inflammation
Intramolecular Oxidoreductases
Kinases
Leukocyte migration
Macrophage migration inhibitory factor
Macrophage Migration-Inhibitory Factors - genetics
Mediators
Mental disorders
MIF
Multiple Sclerosis
Nervous system
Nervous System Diseases
Neurodegeneration
Neurodegenerative diseases
Neuroinflammation
Neurological diseases
Neuromodulation
Pathogenesis
Proteins
Review
Vascular diseases
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Summary:Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a process of unresolved, chronic inflammation. Macrophage migration inhibitory factor, MIF, is an inflammatory mediator that recently gained interest of neuro-researchers due to its varied effects on the CNS such as participation of nervous system development, neuroendocrine functions, and modulation of neuroinflammation. MIF appears to be a candidate as a new biomarker and target of novel therapeutics against numerous neurologic diseases ranging from cancer, autoimmune diseases, vascular diseases, neurodegenerative pathology to psychiatric disorders. In this review, we will focus on MIF's crucial role in neurological diseases such as multiple sclerosis (MS), Alzheimer's disease (AD) and glioblastoma (GBM).
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-023-02993-6