A Study of Controlled Ovarian Stimulation with Clomiphene Citrate or Letrozole in Combination with Gonadotropins and IUI in Unexplained Infertility

To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Non-randomised interventional study. A total number of 60 patients in the a...

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Bibliographic Details
Published in:Journal of human reproductive sciences 2017-07, Vol.10 (3), p.173-177
Main Authors: Hembram, Madhusmita, Biswas, Ratna, Jain, Anju
Format: Article
Language:English
Subjects:
Analysis
Artificial insemination
Biopsy
Care and treatment
Citric acid
Clomiphene
Clomiphene citrate
Comparative analysis
Dosage and administration
Drug dosages
Endometrium
Follicles
Gonadotropins
Gynecology
Immunoassay
Infertility
IUI
Letrozole
Obstetrics
Original
Ovulation
Pituitary (anterior)
Pregnancy complications
Progesterone
Serum levels
Treatment outcome
Ultrasonic imaging
Womens health
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Summary:To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Non-randomised interventional study. A total number of 60 patients in the age group of 20-35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG. In both the groups, ovulation was triggered by hCG followed by intrauterine insemination. The number of follicles on day 8 were significantly higher in the CC + hMG group than that in the letrozole + hMG group. Serum oestradiol level was significantly higher in the CC + hMG group on day 10 and on the day of hCG administration. Pregnancy rate in the CC + hMG group was 23.3% and 13.3% in the letrozole + hMG group. The sequential protocol was cost-effective. CC + hMG could be a preferred ovarian stimulation protocol in couples with unexplained infertility with the added advantage of having no significant complications in properly monitored cycles.
ISSN:0974-1208
1998-4766
DOI:10.4103/jhrs.JHRS_120_16