Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

Opioids mediate their effects opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function an...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2022-06, Vol.15, p.919773
Main Authors: Reeves, Kaitlin C, Shah, Nikhil, Muñoz, Braulio, Atwood, Brady K
Format: Article
Language:English
Subjects:
Anxiety
Brain research
GABA
glutamate
Heroin
Kinases
Ligands
Localization
Morphine
Narcotics
Neuroscience
Neurotransmission
Neurotransmitter release
opioid
Opioid receptors (type delta)
Opioid receptors (type mu)
Peptides
Physiology
Potassium
Proteins
Receptor mechanisms
receptor signal transduction
synaptic plasticity
Synaptic transmission
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Summary:Opioids mediate their effects opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function and synaptic transmission is not uniform in expression pattern and mechanism across the brain. The localization of receptors within specific cell types and neurocircuits determine the effects that endogenous and exogenous opioids have on brain function. In this review we will explore the similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions. We discuss how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2022.919773