Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis

Macrophages are an integral part of the innate immune response in periodontal tissue and play a crucial role in the progression of periodontitis. Here we reported that macrophages also provoke periodontitis-induced gingival destruction through Piezol-mediated collagen degradation. We discovered that...

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Bibliographic Details
Published in:Frontiers in immunology 2023-05, Vol.14, p.1194662-1194662
Main Authors: Zhao, Tong, Chu, Zhuangzhuang, Chu, Catherine Huihan, Dong, Shuo, Li, Guoqing, Wu, Jin, Tang, Chunbo
Format: Article
Language:English
Subjects:
Collagen - metabolism
Gingiva - metabolism
gingival destruction
Humans
Immunology
Ion Channels - metabolism
macrophage
Macrophages - metabolism
matrix metalloproteinases
Matrix Metalloproteinases - metabolism
periodontitis
Periodontitis - metabolism
Piezo1
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Summary:Macrophages are an integral part of the innate immune response in periodontal tissue and play a crucial role in the progression of periodontitis. Here we reported that macrophages also provoke periodontitis-induced gingival destruction through Piezol-mediated collagen degradation. We discovered that the expression was markedly elevated in patients with periodontitis through transcriptomic profiling. Moreover, Piezo1 promoted macrophage polarization toward the M1 type in response to lipopolysaccharide (LPS) and induced production of proinflammatory cytokines, which in turn stimulated production of matrix metalloproteinases (MMPs) leading to collagen degradation. Our study suggests that Piezol might be a potential therapeutic target for treating periodontitis-induced gingival destruction.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1194662