Facile synthesis of cetyltrimethylammonium bromide-loaded mesoporous silica nanoparticles for efficient inhibition of hepatocellular carcinoma cell proliferation

We report the synthesis of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) as efficient anticancer agents. The chemical composition and structure, drug loading capacity, and in vitro cytotoxicity of CTAB-MSNs were analyzed. Our results reveal that CTAB-MSNs displa...

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Bibliographic Details
Published in:Materials research express 2020-08, Vol.7 (8), p.85008
Main Authors: Ai, Fulu, Zhao, Guohua, Lv, Wu, Lin, Jie
Format: Article
Language:English
Subjects:
Anticancer properties
cancer treatment
Cetyltrimethylammonium bromide
Chemical composition
CTAB
Human Hepatoma Cells
mesoporous silica nanoparticles
Nanoparticles
Silicon dioxide
Synthesis
Toxicity
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Summary:We report the synthesis of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) as efficient anticancer agents. The chemical composition and structure, drug loading capacity, and in vitro cytotoxicity of CTAB-MSNs were analyzed. Our results reveal that CTAB-MSNs display a uniform pore structure, extensive surface area, and high drug-loading capacity, of approximately 37.2% by weight. The viability assessments showed that CTAB-MSNs exhibited superior human hepatoma (HepG2) cell killing compared to free CTAB. Therefore, CTAB-MSNs may have advantages over conventional cancer therapies.
ISSN:2053-1591
2053-1591
DOI:10.1088/2053-1591/abad15