A Putative Case of Methotrexate-Related Lymphoma : Clinical Course and PET/CT Findings

Patients with autoimmune conditions develop lymphoproliferative disorders (LPDs) at a higher frequency than normal both in association with and independent of Methotrexate (MTX). We describe a case of MTX-associated lymphoma in a patient with psoriasis on long-standing MTX. The case is notable for t...

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Bibliographic Details
Published in:Case reports in medicine 2009-01, Vol.2009 (2009), p.1-5
Main Authors: Jankowitz, Rachel C., Ganon, James, Blodgett, Todd, Garcia, Christine, Jacobs, Samuel
Format: Article
Language:English
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Case Report
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Summary:Patients with autoimmune conditions develop lymphoproliferative disorders (LPDs) at a higher frequency than normal both in association with and independent of Methotrexate (MTX). We describe a case of MTX-associated lymphoma in a patient with psoriasis on long-standing MTX. The case is notable for the initial tumor burden, the dramatic disappearance of the PET-CT findings on discontinuation of MTX, and the subsequent early regrowth of disease. Our case report is illustrative of an MTX-related NHL in an autoimmune patient. Conclusion. Withdrawal of MTX in a patient with lymphoma is reasonable before initiating chemotherapy, but observation for early regrowth of disease is necessary.
ISSN:1687-9627
1687-9635
DOI:10.1155/2009/469343