Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo . The r...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cell and developmental biology 2021-07, Vol.9, p.685665-685665
Main Authors: Abud, Helen E., Chan, Wing Hei, Jardé, Thierry
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
Epidermal Growth Factor
ErbB
intestinal stem cells
neuregulin 1
niche
signaling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo . The recent identification of diverse stromal cell populations that reside underneath intestinal crypts has enabled the characterization of key growth factor cues supplied by these cells. The nature of these signals and how they are delivered to drive intestinal epithelial development, daily homeostasis and tissue regeneration following injury are being investigated. It is clear that aside from EGF, other ligands of the family, including Neuregulin 1 (NRG1), have distinct roles in supporting the function of intestinal stem cells through the ErbB pathway.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.685665