Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis

Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation is postulated to be a major driver in the progression of liver cirrhosis. H...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.20506-11, Article 20506
Main Authors: Michel, Maurice, Hess, Cornelius, Kaps, Leonard, Kremer, Wolfgang M., Hilscher, Max, Galle, Peter R., Moehler, Markus, Schattenberg, Jörn M., Wörns, Marcus-Alexander, Labenz, Christian, Nagel, Michael
Format: Article
Language:English
Subjects:
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Advanced glycosylation end products
Aged
Ascites
Cirrhosis
Cohort Studies
Etiology
Female
Glycosylation
High-performance liquid chromatography
Humanities and Social Sciences
Humans
Inflammation
Interleukin 6
Liquid chromatography
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - physiopathology
Liver diseases
Liver Function Tests
Male
Mass spectrometry
Mass spectroscopy
Middle Aged
multidisciplinary
Pyruvaldehyde
Pyruvaldehyde - blood
Science
Science (multidisciplinary)
Serum levels
Severity of Illness Index
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Summary:Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation is postulated to be a major driver in the progression of liver cirrhosis. However, the role of circulating MGO levels in liver cirrhosis remains unknown. In this study, we investigated the serum levels of two dicarbonyl species, MGO and glyoxal (GO) using tandem mass spectrometry (HPLC–MS/MS) and evaluated their association with disease severity. A total of 51 inpatients and outpatients with liver cirrhosis of mixed etiology and different disease stages were included. Elevated MGO levels were seen in an advanced stage of liver cirrhosis (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-00119-7