Toxoplasma IgG Expressed in a Patient With Rosai-Dorfman Disease

Rosai-Dorfman Disease (RDD) is a rare benign disease characterized by sinus histiocytosis with massive lymphadenopathy. RDD can be differentiated from other types of histiocytosis by immunochemical analysis, as RDD is positive for S100. Conversely, toxoplasmosis lymphadenitis is characterized by clu...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2010-07, Vol.26 (7), p.373-376
Main Authors: Liao, Hung-Ju, Chiang, Ching-Wen
Format: Article
Language:English
Subjects:
Aged
Antibodies, Protozoan - blood
Antibodies, Protozoan - immunology
Diagnostic Errors
Female
Histiocytosis, Sinus - diagnosis
Histiocytosis, Sinus - immunology
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Internal Medicine
parotid tumor
Rosai-Dorfman disease
Toxoplasma
Toxoplasma - immunology
Toxoplasmosis - diagnosis
Toxoplasmosis - immunology
Toxoplasmosis - parasitology
toxoplasmosis lymphadenopathy
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Summary:Rosai-Dorfman Disease (RDD) is a rare benign disease characterized by sinus histiocytosis with massive lymphadenopathy. RDD can be differentiated from other types of histiocytosis by immunochemical analysis, as RDD is positive for S100. Conversely, toxoplasmosis lymphadenitis is characterized by clusters of epithelioid histiocytes in lymphoid tissue, with mixed lymphocytic and immunoblastic cell populations. The serology data could help in diagnosing toxoplasmosis lymphadenitis, as the toxoplasma IgG should be positive. Here we present the rare case of a 73-year-old woman who presented with a left parotid mass and multiple neck lymphadenopathy that initially had been diagnosed as toxoplasmosis lymphadenitis from a positive result on serology examination, but was finally proven to be RDD based on immunochemical results. We also discuss the relationship between RDD and toxoplasmosis in this case.
ISSN:1607-551X
2410-8650
DOI:10.1016/S1607-551X(10)70061-9