Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?

To evaluate the role of autophagy related gene 7 (ATG7) in non-melanoma skin cancer. This retrospective and prospective case-control study was performed on 104 patients with non-melanoma skin cancer (NMSC) in addition to 20 apparently healthy subjects matched for age and sex as a control group. Mult...

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Bibliographic Details
Published in:Clinical, cosmetic and investigational dermatology cosmetic and investigational dermatology, 2020-01, Vol.13, p.49-58
Main Authors: Samaka, Rehab M, Basha, Mohammed A, Mansour, Eman
Format: Article
Language:English
Subjects:
Antigens
Autophagy
autophagy related gene 7
bcc
Biopsy
Cancer genetics
Cancer research
Dermatologic agents
Epithelium
Genes
Genetic research
Health aspects
Homeostasis
Localization
Medical research
Melanoma
nmsc
Original Research
Pathogenesis
Proteins
scc
Skin cancer
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Summary:To evaluate the role of autophagy related gene 7 (ATG7) in non-melanoma skin cancer. This retrospective and prospective case-control study was performed on 104 patients with non-melanoma skin cancer (NMSC) in addition to 20 apparently healthy subjects matched for age and sex as a control group. Multiple skin biopsies were taken for immunohistochemical evaluation of ATG7 expression. Both epithelial and stromal ATG7 were expressed in all participants while all patients showed nucleocytoplasmic localization and controls showed both cytoplasmic and nucleocytoplasmic expression. In addition, significantly higher H-scores of ATG7 in both epithelium and stroma were detected in patients compared to controls (
ISSN:1178-7015
1178-7015
DOI:10.2147/CCID.S222051