Enhancing IVF Success in Challenging Infertility Cases: The Role of PRGF, GH, and Endometrial Optimization

Infertility in patients with reduced ovarian reserve and thin endometrial lining continues to pose a great challenge for successful in vitro fertilization. In the present case, a patient with a thin endometrium and low ovarian reserve resulted in a positive pregnancy with a specific IVF treatment pl...

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Bibliographic Details
Published in:Journal of pharmacy & bioallied science 2024-12, Vol.16 (Suppl 4), p.S4017-S4020
Main Authors: Dakre, Sudhanshu, Shrivastava, Jarul, Anjankar, Namrata, Shrivastava, Deepti, More, Aakash, Ulhe, Shradha M
Format: Article
Language:English
Subjects:
embryos
Endometrium
Fertilization in vitro
Growth factors
Growth hormones
Hatching
Implantation
In vitro fertilization
Infertility
oocytes
Pregnancy
Somatotropin
sperm
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Summary:Infertility in patients with reduced ovarian reserve and thin endometrial lining continues to pose a great challenge for successful in vitro fertilization. In the present case, a patient with a thin endometrium and low ovarian reserve resulted in a positive pregnancy with a specific IVF treatment plan. It included plasma-rich growth factors, growth hormone, supplementation along with some interventional support of endometrial scratching, and assisted hatching. Endometrial scratching and assisted hatching further optimized implantation potential. The use of these interventions hence promoted successful implantation of the embryo that contributed to positive pregnancy outcome and the birth of a healthy baby at 39 weeks. This case showed how individual ongoing comprehensive treatments definitively made a huge difference in the success of reproductive medicine.
ISSN:0976-4879
0975-7406
DOI:10.4103/jpbs.jpbs_1399_24