The Cerebrospinal Fluid in Multiple Sclerosis

Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria due to its good diagnostic accuracy and increasing issues with misdiagnosis of MS based on over interpretation of...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2019, Vol.10, p.726-726
Main Authors: Deisenhammer, Florian, Zetterberg, Henrik, Fitzner, Brit, Zettl, Uwe K
Format: Article
Language:English
Subjects:
1987
adhesion molecules
axonal damage
biomarker
clinically isolated syndrome
CSF (cerebrospinal fluid)
diagnostic-criteria
disease-activity
Immunologi
Immunology
intrathecal igm-synthesis
journal of neurology
lman ch
multiple sclerosis
natalizumab treatment
neurofilament light
neurofilament light (NfL)
neurofilament light-chain
neuromyelitis-optica
oligoclonal band (OCB)
oligoclonal bands
p19
soluble
v234
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria due to its good diagnostic accuracy and increasing issues with misdiagnosis of MS based on over interpretation of neuroimaging results. The hallmark of MS-specific changes in CSF is the detection of oligoclonal bands (OCB) which occur in the vast majority of MS patients. Lack of OCB has a very high negative predictive value indicating a red flag during the diagnostic work-up, and alternative diagnoses should be considered in such patients. Additional molecules of CSF can help to support the diagnosis of MS, improve the differential diagnosis of MS subtypes and predict the course of the disease, thus selecting the optimal therapy for each patient.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00726