Circadian Rhythms and Mitochondria: Connecting the Dots

Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evidence suggests that metabolic diseases are l...

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Bibliographic Details
Published in:Frontiers in genetics 2018-10, Vol.9, p.452-452
Main Authors: Sardon Puig, Laura, Valera-Alberni, Miriam, Cantó, Carles, Pillon, Nicolas J
Format: Article
Language:English
Subjects:
acetylation
AMPK
circadian rhythm
Genetics
HIF1α
Medicin och hälsovetenskap
metabolism
mitochondria dynamics
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Summary:Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evidence suggests that metabolic diseases are linked to perturbed clock machinery. The circadian clock regulates many transcriptional-translational processes influencing whole cell metabolism and particularly mitochondrial activity. In this review, we survey the current literature related to cross-talks between mitochondria and the circadian clock and unravel putative molecular links. Understanding the mechanisms that link metabolism and circadian responses to transcriptional modifications will provide valuable insights toward innovative therapeutic strategies to combat the development of metabolic disease.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2018.00452