Neuropathic pain in primary knee osteoarthritis patients: correlation with physical function, quality of life, disease severity, and serum beta nerve growth factor levels

Background Neuropathic mechanisms are thought to play a role in knee osteoarthritis (KOA) pain. Neuropathic pain questionnaires can promote diagnosis of a neuropathic component. Thus, we aimed to assess the frequency of neuropathic pain in primary KOA patients (using clinical questionnaires) and to...

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Bibliographic Details
Published in:Egyptian Rheumatology and Rehabilitation 2021-12, Vol.48 (1), p.37-9, Article 37
Main Authors: Kamel, Shereen R., Ibrahim, Radwa S., Moens, Hend M., Mohammed, Rania M.
Format: Article
Language:English
Subjects:
(DN4) questionnaire
(LANSS) questionnaire
Body mass index
Chronic pain
Diabetes
Growth factors
Illiteracy
Knee
Knee osteoarthritis
Males
Medicine
Medicine & Public Health
Neuropathic pain
Osteoarthritis
Patients
Quality of life
Questionnaires
Regression analysis
Rehabilitation
Rheumatism
Rheumatoid arthritis
Serum β-NGF
Sociodemographics
Statistical analysis
Trauma
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Summary:Background Neuropathic mechanisms are thought to play a role in knee osteoarthritis (KOA) pain. Neuropathic pain questionnaires can promote diagnosis of a neuropathic component. Thus, we aimed to assess the frequency of neuropathic pain in primary KOA patients (using clinical questionnaires) and to investigate its correlation with socio-demographic factors, physical function, quality of life, disease severity, and serum beta nerve growth factor (β-NGF) levels. Results Seventy primary KOA patients were included. Neuropathic pain was detected in 52.9% of patients based on Douleur Neuropathique en 4 Questions (DN4) questionnaire and in 38.6% of patients based on Leeds assessment neuropathic pain symptoms and signs questionnaire (LANSS). Serum β-NGF levels were significantly higher in KOA patients than controls ( P
ISSN:1110-161X
2090-3235
DOI:10.1186/s43166-021-00086-x