Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism

This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements. A retrospective study in patients with treated hypothyroidism that underwen...

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Bibliographic Details
Published in:Endocrine regulations (Bratislava) 2022-04, Vol.56 (2), p.81-86
Main Authors: Garcia-Moreno, Rosa Maria, Cos-Blanco, Ana Isabel, Calvo-Vinuela, Isabel, Zapatero-Larrauri, Miriam, Herranz, Lucrecia
Format: Article
Language:English
Subjects:
Bariatric Surgery
Humans
hypothyroidism
Hypothyroidism - drug therapy
levothyroxine
Retrospective Studies
Thyroxine - therapeutic use
Weight Loss
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Summary:This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements. A retrospective study in patients with treated hypothyroidism that underwent bariatric surgery. The modification of the levothyroxine dose and its association with the weight loss and other potential predictors were evaluated at 6, 12, and 24 months post-surgery. Among the 63 patients included, 82.54% needed an adjustment of levothyroxine dose during the follow-up. The total weekly dose of levothyroxine (µg) decreased post-surgery at 6 months (β= −49.1; 95%CI-93.7 to −4.5; p=0.031) and 12 months (β=−54.9; 95%CI-102 to −7.8; p=0.022), but did not significantly change at 24 months (p=0.114). The weekly weight-adjusted dose (µg/k) increased at 6 months (β=1.37; 95%CI 0.91 to 1.83; p
ISSN:1336-0329
1336-0329
DOI:10.2478/enr-2022-0009