Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease

Female Huntington’s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. Cer...

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Bibliographic Details
Published in:Annals of clinical and translational neurology 2021-12, Vol.8 (12), p.2309-2313
Main Authors: Sampedro, Frederic, Martinez‐Horta, Saul, Pérez‐Pérez, Jesús, Perez‐Gonzalez, Rocio, Horta‐Barba, Andrea, Campolongo, Antonia, Aracil‐Bolaños, Ignacio, Gomez‐Anson, Beatriz, Kulisevsky, Jaume
Format: Article
Language:English
Subjects:
Adult
Atrophy - pathology
Biomarkers
Brain
Brief Communication
Brief Communications
Gender differences
Humans
Huntington Disease - cerebrospinal fluid
Huntington Disease - pathology
Huntington Disease - physiopathology
Huntingtons disease
Magnetic Resonance Imaging
Male
Middle Aged
Neurodegeneration
Neurofilament Proteins - cerebrospinal fluid
Patient Acuity
Sex Factors
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Summary:Female Huntington’s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. Cerebrospinal fluid neurofilament light chain (NfL) levels were used as a biological measure of neurodegeneration, and brain atrophy was assessed by structural magnetic resonance imaging. We found that larger NfL values in women reflect higher brain atrophy and clinical severity than in men (p 
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.51460