Advances in Skin Wound and Scar Repair by Polymer Scaffolds

Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scar...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (20), p.6110
Main Authors: Zhou, Shuiqing, Wang, Qiusheng, Huang, Ao, Fan, Hongdou, Yan, Shuqin, Zhang, Qiang
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Cell adhesion
Cell differentiation
Cell Proliferation
Cicatrix - drug therapy
Cicatrix - metabolism
Cicatrix - pathology
Collagen
Cytokines
Extracellular matrix
Growth factors
Humans
Hydrogels
Inflammation
Injuries
Lasers
Morphology
Nanoparticles
Oxygen - metabolism
oxygen generating scaffolds
Pain
polymer scaffolds
Polymers
Polymers - administration & dosage
Polymers - chemistry
Polysaccharides
Pressure distribution
Proteins
Radiation therapy
Review
Rodents
Scaffolds
scar inhibition
Scars
Skin
Skin - drug effects
Skin - metabolism
Skin - pathology
Skin injuries
Stem cells
Tissue engineering
Tissue Scaffolds - chemistry
Trauma
Vascularization
Wound healing
Wound Healing - drug effects
Wound Healing - physiology
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Summary:Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26206110