Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chi...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-02, Vol.28 (3), p.1473
Main Authors: Fan, Peng, Zeng, Yanbo, Zaldivar-Silva, Dionisio, Agüero, Lissette, Wang, Shige
Format: Article
Language:English
Subjects:
Adhesives
Bacterial infections
Biocompatibility
Blood platelets
Blood vessels
Chemical modification
Chemical properties
Chitin
Chitosan
Chitosan - chemistry
Chitosan - pharmacology
Chitosan - therapeutic use
Deacetylation
Erythrocytes
Gels (Pharmacy)
Hemoglobin
Hemorrhage - drug therapy
Hemostasis
Hemostatics
Hemostatics - chemistry
Hemostatics - pharmacology
Hemostatics - therapeutic use
Humans
hydrogel
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogels - therapeutic use
Infections
Mechanical properties
Physiology
Polymers
Production processes
Review
self-healing
Wound healing
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Summary:The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantageous characteristics compared to traditional hemostatic materials. The effects of the hemostatic mechanism, effects of deacetylation degree, relative molecular mass, and chemical modification on the hemostatic performance of CS hydrogels are summarized. Meanwhile, some typical applications of CS hydrogels are introduced to provide references for the preparation of efficient hemostatic hydrogels. Finally, the future perspectives of CS-based hemostatic hydrogels are presented.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28031473