Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs...

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Bibliographic Details
Published in:Biomedicines 2024-08, Vol.12 (8), p.1906
Main Authors: Issa, Shaza, Fayoud, Haidar, Shaimardanova, Alisa, Sufianov, Albert, Sufianova, Galina, Solovyeva, Valeriya, Rizvanov, Albert
Format: Article
Language:English
Subjects:
BDNF
Brain research
Brain-derived neurotrophic factor
Care and treatment
Cell cycle
Cell growth
Degeneration
Disease
Dosage
GDNF
Gene expression
Gene therapy
Genetic disorders
Growth factors
Health aspects
hereditary neurodegenerative diseases
Huntingtons disease
IGF-1
Insulin
Kinases
Metabolism
Methods
Mutation
Nervous system
Neurodegenerative diseases
Patients
Physiology
Protein therapy
Review
Roles
Stem cells
Synaptic plasticity
Transcription factors
Vascular endothelial growth factor
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Summary:Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12081906