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Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs...

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Published in:	Biomedicines 2024-08, Vol.12 (8), p.1906
Main Authors:	Issa, Shaza, Fayoud, Haidar, Shaimardanova, Alisa, Sufianov, Albert, Sufianova, Galina, Solovyeva, Valeriya, Rizvanov, Albert
Format:	Article
Language:	English
Subjects:	BDNF Brain research Brain-derived neurotrophic factor Care and treatment Cell cycle Cell growth Degeneration Disease Dosage GDNF Gene expression Gene therapy Genetic disorders Growth factors Health aspects hereditary neurodegenerative diseases Huntingtons disease IGF-1 Insulin Kinases Metabolism Methods Mutation Nervous system Neurodegenerative diseases Patients Physiology Protein therapy Review Roles Stem cells Synaptic plasticity Transcription factors Vascular endothelial growth factor
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description	Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.
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subjects	BDNF Brain research Brain-derived neurotrophic factor Care and treatment Cell cycle Cell growth Degeneration Disease Dosage GDNF Gene expression Gene therapy Genetic disorders Growth factors Health aspects hereditary neurodegenerative diseases Huntingtons disease IGF-1 Insulin Kinases Metabolism Methods Mutation Nervous system Neurodegenerative diseases Patients Physiology Protein therapy Review Roles Stem cells Synaptic plasticity Transcription factors Vascular endothelial growth factor
title	Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases
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