Migraine: Advances in the Pathogenesis and Treatment

This article presents a comprehensive review on migraine, a prevalent neurological disorder characterized by chronic headaches, by focusing on their pathogenesis and treatment advances. By examining molecular markers and leveraging imaging techniques, the research identifies key mechanisms and trigg...

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Bibliographic Details
Published in:Neurology international 2023-08, Vol.15 (3), p.1052-1105
Main Authors: Pleș, Horia, Florian, Ioan-Alexandru, Timis, Teodora-Larisa, Covache-Busuioc, Razvan-Adrian, Glavan, Luca-Andrei, Dumitrascu, David-Ioan, Popa, Andrei Adrian, Bordeianu, Andrei, Ciurea, Alexandru Vlad
Format: Article
Language:English
Subjects:
Age
calcitonin gene-related peptide (CGRP)
Chronic illnesses
Gender
Headaches
Medical referrals
Migraine
migraine pathogenesis
migraine treatment
molecular markers
neuromodulation
Pediatrics
Review
Socioeconomic factors
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Summary:This article presents a comprehensive review on migraine, a prevalent neurological disorder characterized by chronic headaches, by focusing on their pathogenesis and treatment advances. By examining molecular markers and leveraging imaging techniques, the research identifies key mechanisms and triggers in migraine pathology, thereby improving our understanding of its pathophysiology. Special emphasis is given to the role of calcitonin gene-related peptide (CGRP) in migraine development. CGRP not only contributes to symptoms but also represents a promising therapeutic target, with inhibitors showing effectiveness in migraine management. The article further explores traditional medical treatments, scrutinizing the mechanisms, benefits, and limitations of commonly prescribed medications. This provides a segue into an analysis of emerging therapeutic strategies and their potential to enhance migraine management. Finally, the paper delves into neuromodulation as an innovative treatment modality. Clinical studies indicating its effectiveness in migraine management are reviewed, and the advantages and limitations of this technique are discussed. In summary, the article aims to enhance the understanding of migraine pathogenesis and present novel therapeutic possibilities that could revolutionize patient care.
ISSN:2035-8377
2035-8385
2035-8377
DOI:10.3390/neurolint15030067