Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?

Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for severa...

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Bibliographic Details
Published in:Frontiers in immunology 2023-06, Vol.14, p.1183665
Main Authors: De Waard, Aurianne, Lefebvre, Laurent, Textoris, Julien, Payen, Didier
Format: Article
Language:English
Subjects:
acute immuno-depression syndrome
ARDS (acute respiratory disease syndrome)
Coinfection - drug therapy
COVID 19
HLA-DR
HLA-DR Antigens - metabolism
Humans
Immune Tolerance
Immunology
interferon gamma (IFNγ)
Interferon-gamma - pharmacology
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Summary:Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for several weeks. The occurrence of secondary infections despite long treatment by antibiotics led to combined interferon γ (IFNγ) as reported previously. The response to IFNγ was evaluated by the flowcytometry HLA-DR expression on circulating monocytes, which was repeated from time to time. The severe COVID-19 patients responded well to IFNγ without adverse events.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1183665