When Oxidative Stress Meets Epigenetics: Implications in Cancer Development

Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequen...

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Bibliographic Details
Published in:Antioxidants 2020-06, Vol.9 (6), p.468
Main Authors: García-Guede, Álvaro, Vera, Olga, Ibáñez-de-Caceres, Inmaculada
Format: Article
Language:English
Subjects:
cancer
Cancer metastasis
cancer therapy
chemoresistance
Epigenetic inheritance
epigenetics
Genetic aspects
Health aspects
miR7/MAFG/Nrf2 axe
Oxidative stress
Review
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Summary:Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9060468