Translating regenerative medicine techniques for the treatment of epilepsy

Epilepsy is considered a chronic neurological disorder and is accompanied by persistent and diverse disturbances in electrical brain activity. While antiepileptic pharmaceuticals are still the predominant treatment for epilepsy, the advent of numerous surgical interventions has further improved outc...

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Bibliographic Details
Published in:Brain circulation 2017-07, Vol.3 (3), p.156-162
Main Authors: Yasuhara, Takao, Date, Isao, Liska, M Grant, Kaneko, Yuji, Vale, Fernando L
Format: Article
Language:English
Subjects:
Angiogenesis
Care and treatment
central nervous system disorders
electrical stimulation
Epilepsy
Hypotheses
Kinases
Medicine
Mortality
Neurogenesis
neuroprotective agents
Neurosurgery
Parkinson's disease
Patients
Regenerative medicine
Review
Rodents
Stem cells
stem-cell therapy
Stroke
Surgery
Transplantation
Transplants & implants
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Description
Summary:Epilepsy is considered a chronic neurological disorder and is accompanied by persistent and diverse disturbances in electrical brain activity. While antiepileptic pharmaceuticals are still the predominant treatment for epilepsy, the advent of numerous surgical interventions has further improved outcomes for patients. Despite these advancements, a subpopulation continues to experience intractable seizures which are resistant to current conventional and nonconventional therapeutic options. In this review, we begin with an introduction to the clinical presentation of epilepsy before discussing the clinically relevant laboratory models of epilepsy. Finally, we explore the implications of regenerative medicine - including cell therapy, neuroprotective agents, and electrical stimulation - for epilepsy, supplemented with our laboratory's data. This paper is a review article. Referred literature in this paper has been listed in the references section. The datasets supporting the conclusions of this article are available online by searching various databases, including PubMed. Some original points in this article come from the laboratory practice in our research center and the authors' experiences.
ISSN:2394-8108
2455-4626
2455-4626
DOI:10.4103/bc.bc_21_17