COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient

Acute generalised exanthematous pustulosis (AGEP) is an unusual cutaneous reaction, most often related with a hypersensitivity reaction to commonly used drugs. It is characterized by an abrupt onset of a pustular rash within hours or days after drug exposure and usually resolves spontaneously within...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 2021-01, Vol.63, p.1-5
Main Authors: Ordoñez, Nicolás Ariza, Sepulveda, Valeria Gomez, Vargas, Lina Patricia, Moreno, Julian Mauricio
Format: Article
Language:English
Subjects:
Antibiotics
Biopsy
Blood
Case Report
Coronaviruses
COVID-19
Cytokines
Drugs
Infections
Metabolism
Neutrophils
Pneumonia
Psoriasis
SARS CoV-2
Sepsis
Shock
Skin
Skin manifestations
TROPICAL MEDICINE
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Summary:Acute generalised exanthematous pustulosis (AGEP) is an unusual cutaneous reaction, most often related with a hypersensitivity reaction to commonly used drugs. It is characterized by an abrupt onset of a pustular rash within hours or days after drug exposure and usually resolves spontaneously within 1-2 weeks after drug discontinuation. Some cases associated with systemic involvement and shock have been reported. We present the case of a severe AGEP, manifesting in association with systemic involvement and haemodynamic instability resulting in shock and multiorgan dysfunction in an adult female patient diagnosed with COVID-19 infection. There were no identifiable associated drugs, and the patient was not initiated on antimalarial drugs. Our patient improved rapidly, both hemodynamically and dermatologically with no directed therapy.
ISSN:1678-9946
0036-4665
1678-9946
DOI:10.1590/S1678-9946202163042