Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury

Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system neuroinflammation. But its precise roles in these processes and involvement in spinal cord injury pathophysiology remain unclear. Western blot assay revealed...

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Bibliographic Details
Published in:Neural regeneration research 2021-07, Vol.16 (7), p.1331-1335
Main Authors: E. Weerasinghe-Mudiyanselage, Poornima, Kim, Jeongtae, Choi, Yuna, Moon, Changjong, Shin, Taekyun, Ahn, Meejung
Format: Article
Language:English
Subjects:
astrocytes
clip compression injury
macrophage
microglia
neuroinflammation
ninjurin-1
rat
spinal cord
Biological markers
Biomarkers
Care and treatment
Diagnosis
Health aspects
Identification and classification
Inflammation
Laboratory animals
Pathophysiology
Spinal cord injuries
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Summary:Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system neuroinflammation. But its precise roles in these processes and involvement in spinal cord injury pathophysiology remain unclear. Western blot assay revealed that Ninjurin-1 levels in rats with spinal cord injury exhibited an upregulation until day 4 post-injury and slightly decreased thereafter compared with sham controls. Immunohistochemistry analysis revealed that Ninjurin-1 immunoreactivity in rats with spinal cord injury sharply increased on days 1 and 4 post-injury and slightly decreased on days 7 and 21 post-injury compared with sham controls. Ninjurin-1 immunostaining was weak in vascular endothelial cells, ependymal cells, and some glial cells in sham controls while it was relatively strong in macrophages, microglia, and reactive astrocytes. These findings suggest that a variety of cells, including vascular endothelial cells, macrophages, and microglia, secrete Ninjurin-1 and they participate in the pathophysiology of compression-induced spinal cord injury. All experimental procedures were approved by the Care and Use of Laboratory Animals of Jeju National University (approval No. 2018-0029) on July 6, 2018.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.301033