Identification of novel circulating microRNAs in advanced heart failure by next‐generation sequencing

Aims Risk stratification in patients with advanced chronic heart failure (HF) is an unmet need. Circulating microRNA (miRNA) levels have been proposed as diagnostic and prognostic biomarkers in several diseases including HF. The aims of the present study were to characterize HF‐specific miRNA expres...

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Bibliographic Details
Published in:ESC Heart Failure 2021-08, Vol.8 (4), p.2907-2919
Main Authors: Galluzzo, Alessandro, Gallo, Simona, Pardini, Barbara, Birolo, Giovanni, Fariselli, Piero, Boretto, Paolo, Vitacolonna, Annapia, Peraldo‐Neia, Caterina, Spilinga, Martina, Volpe, Alessandra, Celentani, Dario, Pidello, Stefano, Bonzano, Alessandro, Matullo, Giuseppe, Giustetto, Carla, Bergerone, Serena, Crepaldi, Tiziana
Format: Article
Language:English
Subjects:
Age
Beta blockers
Biomarkers
Body mass index
Cardiac catheterization
Cardiovascular disease
Circulating microRNAs
Coronary vessels
Creatinine
Diabetes
Electrocardiography
Etiology
Gender
Heart failure
Hypertension
Intubation
Kidney diseases
Laboratories
Maximum oxygen consumption
MicroRNAs
Original
Original s
Patients
Peptides
Plasma
Pulmonary arteries
Risk stratification
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Summary:Aims Risk stratification in patients with advanced chronic heart failure (HF) is an unmet need. Circulating microRNA (miRNA) levels have been proposed as diagnostic and prognostic biomarkers in several diseases including HF. The aims of the present study were to characterize HF‐specific miRNA expression profiles and to identify miRNAs with prognostic value in HF patients. Methods and results We performed a global miRNome analysis using next‐generation sequencing in the plasma of 30 advanced chronic HF patients and of matched healthy controls. A small subset of miRNAs was validated by real‐time PCR (P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13371